Virginio Orsini (September 1572 – 9 September 1615) was the second Duke of Bracciano, a member of the Orsini family.
He was the son of Paolo Giordano I Orsini and Isabella de' Medici, and inherited his father titles and fiefs after his death in 1585. His son Paolo Giordano became a prince of the Holy Roman Empire through his marriage with Isabella Appiani, princess of Piombino.
He died in Rome in 1615.
| Preceded by Paolo Giordano I Orsini |
Duke of Bracciano 1585–1615 |
Succeeded by Paolo Giordano II Orsini |